FGF21 and Cardiac Physiopathology

FGF21 and Cardiac Physiopathology

The heart is not traditionally considered either a target or a site of fibroblast growth factor-21 (FGF21) production. However, recent findings indicate that FGF21 can act as a cardiomyokine; that is, it is produced by cardiac cells at significant levels and acts in an autocrine manner on the heart itself. The heart is sensitive to the effects of FGF21, both systemic and locally generated, owin...

FGF21 deletion exacerbates diabetic cardiomyopathy by aggravating cardiac lipid accumulation

Fibroblast growth factor 21 (FGF21) plays an important role in energy homoeostasis. The unaddressed question of FGF21's effect on the development and progression of diabetic cardiomyopathy (DCM) is investigated here with FGF21 knockout (FGF21KO) diabetic mice. Type 1 diabetes was induced in both FGF21KO and C57BL/6J wild-type (WT) mice via streptozotocin. At 1, 2 and 4 months after diabetes ons...

[Physiopathology of melasma].

Melasma is a common dermatosis that involves changes in normal skin pigmentation, resulting from the hyperactivity of epidermal melanocytes. The consequent hyperpigmentation is mostly induced by ultraviolet radiation. Clinically, melasma is characterized by light to dark brown macules that usually occur on the face, although they can also affect the cervical and anterior thoracic regions and up...

Physiopathology of Allergy

Cardiac Fgf21 synthesis and release: an autocrine loop for boosting up antioxidant defenses in failing hearts.

Fibroblast growth factors (Fgfs) are signalling proteins of 150–300 amino acids with diverse functions, mainly in development and metabolism. The human/mouse Fgf family comprises 22 members. Fgfs can be classified as intracellular, paracrine, and endocrine Fgfs by their action mechanisms. Among Fgfs, Fgf2, Fgf16, Fgf21, and Fgf23 have been shown to be cardiomyokines playing pathophysiological r...